• COVID-19
  • Allergies and Infant Formula
  • Pharmacology
  • Telemedicine
  • Drug Pipeline News
  • Influenza
  • Allergy, Immunology, and ENT
  • Autism
  • Cardiology
  • Emergency Medicine
  • Endocrinology
  • Adolescent Medicine
  • Gastroenterology
  • Infectious disease
  • Nutrition
  • Neurology
  • Obstetrics-Gynecology & Women's Health
  • Developmental/Behavioral Disorders
  • Practice Improvement
  • Gynecology
  • Respiratory
  • Dermatology
  • Diabetes
  • Mental Health
  • Oncology
  • Psychiatry
  • Animal Allergies
  • Alcohol Abuse
  • Rheumatoid Arthritis
  • Sexual Health
  • Pain

Pollution and deprivation increase risk of congenital heart disease


The development of congenital heart disease has many potential factors. New research indicates that maternal exposure to pollutants and deprivation can increase the risk of the disease for their offspring.

The factors that can lead to the development of congenital heart disease (CHD) are myriad. A new study in the Journal of the American Heart Association examined the relationship between environmental and socioeconomic factors and the incidence of CHD among live-born infants in the state of California.1

Investigators used US Census data to determined socioeconomic status and environmental exposure to pollutants. They developed a social deprivation and environmental exposure index that was split into 4 quartiles, with quartile 1 having the least exposure to pollutants and social deprivation and quartile 4 having the most exposure.

In the cohort of 2,419,651 live-born infants and a subcohort of 7698 infants with CHD, the incidence of CHD was 3.2 per 1000 live births. Researchers found the incidence of CHD was significantly higher among infants who were in quartile 4 than infants who were in quartile 1. The incidence remained after adjusting for maternal race/ethnicity and taking into account the potential relationship between social deprivation and exposure to pollutants. They also found that maternal comorbidities could explain 13% of the link between CHD and social deprivation and environmental exposure.

The researchers concluded that the findings of their study illustrate targets that government policies should address to minimize health outcome disparities.


1.    Peyvandi S, Baer RJ, Chambers CD, et al. Environmental and socioeconomic factors influence the live-born incidence of congenital heart disease: a population-based study in California. J Am Heart Assoc. 2020;9(8):e015255. doi: 10.1161/JAHA.119.015255

Related Videos
Scott Ceresnak, MD
Importance of maternal influenza vaccination recommendations
Reducing HIV reservoirs in neonates with very early antiretroviral therapy | Deborah Persaud, MD
Samantha Olson, MPH
Deborah Persaud, MD
Ari Brown, MD, FAAP | Pediatrician and CEO of 411 Pediatrics; author, baby411 book series; chief medical advisor, Kabrita USA.
Steven Selbst, MD
© 2024 MJH Life Sciences

All rights reserved.