Case Studies

A 16-month-old with recurrent otitis media developed a spreading unilateral rash on her hip and thigh during antibiotic treatment. PCR testing confirmed herpes zoster, an uncommon diagnosis in young, vaccinated children.

Can you guess the diagnosis?

Can you guess the diagnosis?

Can you guess the diagnosis?

Can you guess the diagnosis?

Can you guess the diagnosis?

Find out the correct diagnosis of this 19-year-old boy with Down syndrome and progressive loss of communication.

Can you guess the diagnosis?

Can you correctly guess the diagnosis?

Join us for a recap of some of our top dermatology Puzzler cases from 2025.

Can you guess what condition Tiny Tim had?

See the full case of our most recent Puzzler quiz and view the correct diagnosis of this 19-year-old woman with painful, purpuric nodules in the phalanges of her fingers.

Can you guess the diagnosis?

See the full case of our most recent puzzler quiz, and view the correct diagnosis of this slender teen with a growing abdomen and shrinking height.

Can you guess the diagnosis?

Can you guess the diagnosis?

The patient's physical exam is notable for a tan colored lesion on the left eye that Mom states has been present since birth. Can you guess the diagnosis?

Can you guess the diagnosis?

The patient was discharged after symptoms improved with antiemetics and pain medications.

Can you guess the diagnosis?

Can you diagnose this 10-year-old with an oozy ear?

He had no prior history of recurrent ear infections, abscesses, or boils. Can you guess the diagnosis?

Can you guess the diagnosis?

Try to diagnose this patient with 3 days of right-sided neck swelling.

Try to diagnose this patient with a history of receptive-expressive speech disorder and anxiety.

Try to diagnose this patient with a history of receptive-expressive speech disorder and anxiety.

A recently immigrated mother from India presents in preterm labor at 32 6/7 weeks and delivers a vigorous baby whose initial blood culture is positive at 18 hours of life with gram-negative rods.

A recently immigrated mother from India presents in preterm labor at 32 6/7 weeks and delivers a vigorous baby whose initial blood culture result is positive at 18 hours of life with gram-negative rods.