Developmental/Behavioral Disorders

ConSynance Therapeutics' CSTI-500, an innovative Triple Monoamine Reuptake Inhibitor, has received FDA's Rare Pediatric Disease Designation for treating Prader-Willi Syndrome in children.

From baseline to final assessment, all 7 matched cerliponase alfa-treated children under 3 years of age maintained a motor score of 3, representing a "grossly normal gait, signifying a delay in disease onset," stated BioMarin.

A laboratory-based assessment shows children aged 18 - 32 months old were less likely to listen to attention prompts or their parent's requests when provided an iPad versus a standard toy.

Investigators therefore concluded that ROAR provides an excellent way to identify children at highest risk of having poor reading skills.

Overall, the findings of the study support the clinical utility of combining trio-WES sequencing with CNV-seq in the etiologic diagnosis and management of early-childhood GDD.

Donna Hallas, PhD, PPCNP-BC, CPNP, PMHS, FAANP, FAAN, shares her thoughts on the latest issue of Contemporary Pediatrics and how these articles can be utilized in the everyday practice of PNPs.

Investigators aimed to assess effectiveness of early and continuous enrichment intervention on motor, cognitive, and functional skills in infants with CP.

Study in JAMA: Antenatal corticosteroids don't impact neurodevelopment in late preterm children aged 6 years and up.

An assessment into development scores before, during and after the COVID-19 pandemic show children aged 0 - 5 years old may only had been minimally impacted in communication and problem-solving skills.

A recently published study in JAMA sought to determine if there is a link between acetaminophen use during pregnancy and children’s risk of developing autism, ADHD, or intellectual disabilities.

HCPs can provide resources to help parents make an informed decision.

The single-arm study has an estimated enrollment of 93 participants, made up of females aged 2 to 8 years and males aged 2 to 9 years with CPP.

Results demonstrated that foster care involvement does vary based on age and sex, with Black youths and females disproportionately effected.

Compared to children with no maternal tobacco usage during pregnancy, those exposed had associations to childhood neurocognition deficits.

The approach can improve mental health and various subgroups such as cognitive function, psychological well-being, and more.

A new recommendation statement from the Preventive Services Task Force remains inconclusive on the benefits versus risks of asymptomatic screening for speech and language delay disorders.

Investigators of a new study published in JAMA Pediatrics concluded that maternal vaccination was safe with regard to neurodevelopment of the child at ages 12 months and 18 months.

Children of mothers in minority groups were associated with a higher likelihood of ASD diagnosis, but only children of White mothers had ASD associated with neighborhood disadvantages.

In this Q&A, Kristine H. Schmitz, MD, explains her team's recent research on paternal depression and adverse childhood experiences during the 2023 American Academy of Pediatrics National Conference & Exhibition.

A systematic review and meta-analysis found that such sequencing indeed has an equivalent high genetic diagnostic yield in cerebral palsy, which supports including this neurodevelopmental disorder among those for which diagnostic exome sequencing should be used.

To assess the role of familial factors, investigators analyzed data for a family-based group created from another Swedish national register that included 833,172 individuals without ADHD with different levels of relatedness to the individuals with ADHD and a group of matched controls.

An increased risk of cerebral palsy was observed in children conceived in the winter and spring compared to summer, according to a recent study published in JAMA Network Open.

Francheska M. Merced-Nieves, PhD, Assistant professor, Departments of Pediatrics and the Institute for Exposomic Research of Environmental Medicine & Public Health, Icahn School of Medicine at Mount Sinai, explains the associations prenatal exposure to a metal mixture and the potential negative effects for the infant.

Study authors concluded that developmental delay domains should be separately considered when discussing screen time and potential delays in childhood development.

Children followed up with at 5 years of age that were exposed to the COVID-19 pandemic were 4.39 months behind in overall childhood development, whereas children followed up with at 3 years of age demonstrated positive associations.

In a recent study, long-term neurodevelopmental outcomes were improved in children of parents receiving pravastatin compared to placebo.

The prospective cohort study evaluates the role of both subjective and objective experiences.

Due to a lack of evidence, the US Preventive Services Task Force (USPSTF) did not make a recommendation for or against screening for speech and delay disorder in all children 5 years or younger by primary health care professionals.

In this study, investigators focused on children with Fetal Alcohol Spectrum Disorder (FASD), who are known to experience significant sleep disturbances.

A family-centered procedural sedation protocol for children with autism spectrum disorder (ASD) or developmental delay (DD) allowed 93% of patients to be free of restraints during routine health care procedures.