The search for a better way to screen infants for iron deficiency

Article

Investigators compared measurement of reticulocyte hemoglobin content (CHr) with measurement of hemoglobin as a means of screening healthy infants for iron deficiency. Of 202 9- to 12-month-old infants initially enrolled in a prospective study, 23 (11.4%) had iron deficiency and six (3%) had iron deficiency and anemia, as gauged by transferrin saturation and hematologic parameters. From this initial group, 147 infants (none with anemia) were rescreened for iron deficiency at subsequent well-baby visits over a median of 5.6 months.

Infants who were iron-deficient, as well as those who were not, had significantly different values for all measured biochemical and hematologic markers of iron deficiency. Investigators identified a CHr threshold of <27.5 pg for detecting iron deficiency in infants at initial screening. Overall, reticulocyte hemoglobin content was more accurate than hemoglobin for detecting iron deficiency.

In addition, CHr <27.5 pg without anemia at initial screening was associated with anemia at screening a year later. Of 45 nonanemic infants with CHr <27.5 pg at initial screening, four developed anemia. But only one of the 102 nonanemic infants with CHr <27.5 or higher at initial screening was anemic at follow-up (Ullrich C et al: JAMA 2005;294:924).

Newsletter

Access practical, evidence-based guidance to support better care for our youngest patients. Join our email list for the latest clinical updates.

Recent Videos
Stephanie Anne Deutsch, MD, MS, MSCR, FAAP
Erica Prochaska, MD
Reducing HIV reservoirs in neonates with very early antiretroviral therapy | Deborah Persaud, MD
Deborah Persaud, MD
Related Content
© 2025 MJH Life Sciences

All rights reserved.