Is botulinum toxin effective for treating children’s migraines?

Contemporary PEDS JournalVol 37 No 9
Volume 37
Issue 9

A new study examines the efficacy of the toxin for migraine treatment in pediatrics.

"Perhaps” might be the best answer to this question, based on a review of the literature on use of botulinum toxin for treating pediatric chronic migraine. Seven studies with from 1 to 30 participants were included in the review: 2 retrospective analyses, 3 case series, a case report, and a single randomized controlled trial with 125 patients. The number of treatments ranged from 1 to 11, and dosing and injection protocols varied. Only the randomized controlled trial had fixed protocols; the other studies combined a fixed protocol with one that “followed the pain.” Dosages ranged from 100 to 215U, with treatment given about every 3 months.

The randomized controlled trial found no benefit to botulinum toxin compared with placebo. The other studies noted clinically significant benefits for headache frequency, migraine intensity, or migraine duration. Two studies found that headache frequency decreased 50% whereas others noted even greater decreases of 74% and 97%. Decrease in migraine intensity ranged from 25% to 100%. The one study that measured migraine duration showed a median decrease from 8 to 0.75 hours. Side effects were minimal in most studies, generally injection site pain and tenderness (Marcelo R, et al. J Child Neurol. 2020; Epub ahead of print).

Thoughts from Dr. Farber

We can add botulinum toxin to the long list of proposed treatments for pediatric migraine that possibly are worth trying but are not yet proven in large enough randomized, controlled trials. Others on this list include antiepileptics, tricyclics, SSRIs, beta-blockers, and antihistamine medications, as well as cognitive behavioral therapy.

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