FDA approves dupilumab for chronic spontaneous urticaria in ages 12 and up
The sBLA for dupilumab (Dupixent) was supported by data from the phase 3 LIBERTY-CUPID clinical program in patients with uncontrolled CSU.
Viral studies reduce antibiotic use in hospitalized febrile infants
"Testing for viruses should be the standard of care to help guide therapy," stated Jon Matthew Farber, MD.
ACIP votes in favor of recently FDA approved vaccines for meningococcal disease, chikungunya
Recommendations from the ACIP are forwarded to the director of the CDC, and if adopted, become official CDC policy.
Full case: 2-month-old with scalp swelling
FDA expands diazepam nasal spray for seizure clusters to ages 2–5
Diazepam nasal spray (Valtoco) is approved for short-term treatment of seizure clusters, now in patients aged 2 years and older.
Stephanie Chao, MD details relationships in mass shootings involving children
Recent research detailed that a child was most likely to be killed in a mass shooting by a parent or family member vs a stranger or peer. Study investigator Stephanie Chao, MD, breaks down these data.
Preterm skin-to-skin contact does not improve neurodevelopment at 2–3 years
In the immediate skin-to-skin contact group, improved breastfeeding practices up to 12 months were observed.
Six months of breastfeeding tied to lower risk of developmental delays
Breastfeeding for 6 months was linked to fewer developmental delays and neurodevelopmental conditions, supporting current recommendations.
Child dehydration: Early signs to watch for
Their smaller size, higher metabolic rate, and greater body water percentage mean they lose fluids more quickly.
Identifying motor milestone delay can lead to earlier autism diagnosis
Overall, findings revealed that a higher proportion of children with autism had a history of motor milestone delays.
FDA approves maralixibat tablet formulation for ALGS and PFIC
In the United States, maralixibat (Livmarli; Mirum Pharmaceuticals) is approved to treat both ALGS and PFIC, now in liquid and tablet formulations.
Preterm birth associated with long-term cognitive issues in children
Infants born moderately preterm had lower composite cognitive scores compared to those born at full-term s (β = −0.39; 95% CI, −0.55 to −0.22; P < .001).
Weekly review: Strong plaque psoriasis data, our April issue, and more
From strong data for JNJ-2113 to a deep dive into climate change and pediatric health care, get caught up with our weekly review article.
IL-6 may aid in early sepsis detection in children, newborns
A recent study found IL-6 may help with earlier sepsis detection in pregnant women, children, and newborns, outperforming traditional diagnostic tests.
Quiz: AAP critical congenital heart disease screening recommendations
Do you know the details from the American Academy of Pediatrics' 2024 CCHD updated screening recommendations?
Talking to parents about seed oils
While these concerns are often rooted in misinformation, they offer an opportunity to guide families back to the evidence.
JNJ-2113 for plaque psoriasis demonstrates clear skin in 75% of adolescents
“Data from the Phase 3 ICONIC LEAD subgroup analysis demonstrate impressive efficacy rates, showing the promise of this novel therapeutic option," said Lawrence Eichenfield, MD.
Most US teen girls live in states with abortion limits
Two-thirds of US teen girls live in states with abortion bans, gestational limits, or parental involvement laws, limiting access to care.
Climate change: Challenges faced by the pediatric population
The World Bank Group reports that as this global health emergency escalates, devastating impacts on health and well-being will also accelerate.
FDA approves nivolumab with ipilimumab for MSI-H, dMMR colorectal cancer
The federal agency greenlit nivolumab with ipilimumab for treating MSI-H/dMMR colorectal cancer in adults and children 12 years and up.
CBD may ease autism symptoms in children
CBD cannabis extract may improve social responsiveness and reduce disruptive behavior in children with autism, with no increase in adverse effects, according to a recent study
Feasibility of ambulatory blood pressure monitoring in primary care
Ambulatory blood pressure monitoring at point-of-care shows high feasibility for pediatric hypertension diagnosis in clinical practice.
Uncharacteristic skin findings in a toddler with a history of dermatitis
The patient’s medical history included several episodes of mild diaper dermatitis and erythematous rashes during periods of teething.
USPSTF issues new recommendation for breastfeeding support interventions
Primary care interventions, such as education and support, effectively promote breastfeeding up to 6 months, improving rates of any and exclusive breastfeeding, according to the USPSTF.
Strengthening allergy awareness in children and teens
Allergies can significantly impair daily activities, school performance, and psychological well-being.
Preventing deficiencies in pediatric food allergies
Distinguishing between food allergies and intolerances is crucial.
FDA accepts sBLA to expand fremanezumab-vfrm indication for episodic migraines in children
If approved, the expanded indication would include children and adolescents aged 6 to 17 years who weigh 99 lbs (45 kg) or more.
Setmelanotide demonstrates BMI reduction in patients with acquired hypothalamic obesity
In the phase 3 TRANSCEND trial, setmelanotide met the primary endpoint of a statistically significant and clinically meaningful BMI reduction compared to placebo.
Early-life ozone exposure linked to increased risk of asthma and wheeze in young children
A new study published in JAMA Open Network suggests that early-life exposure to ambient ozone (O3) may contribute to an increased risk of asthma and wheeze in young children.
Full case: 21-month-old with history of “skin tags” on her gluteal cleft
Read the full case presentation of a 21-month-old with a history of "skin tags" involving her gluteal cleft,noted at birth.
