5 puzzling cases to test your diagnostic skills

Test your diagnostic skills with 5 puzzling cases that we featured in 2021.

Can you solve these 5 cases?

Red papulonodule with central crusting on a neonate’s cheek

A newborn boy born via normal vaginal delivery at 38.6 weeks gestation to a 33-year-old G5P2022 mother presented at birth with an asymptomatic 8-mm red, papulonodule with central crusting on the right cheek. What's the diagnosis?

Adolescent in detention center presents with hallucinations

A 17-year-old boy with a history of anxiety was transported from a juvenile detention center for altered mental status, including hallucinations and agitation. What's the diagnosis?

A 3-week-old girl with vesicular rash

A 3-week old girl comes to an emergency room with vesicular eruptions and recent mild nasal congestion and fussiness. What’s the diagnosis?

Pleuropulmonary blastoma in an adolescent

A previously healthy 16-year-old female patient presents with intermittent pleuritic chest pain and shortness of breath. The night before her symptoms started, she hit her chest on a door after a "fainting" episode. What's the diagnosis?

Persistent foot and leg swelling in a 17-year-old female

A 17-year-old girl presents with a 2-year history of unilateral swelling of the left lower extremity as well as a poorly healed ankle sprain of the affected extremity 3 years prior that slowly resolved but left persistent swelling. What's the diagnosis?