Neurology

Get caught up with our journal! Review some of the top stories from the Contemporary Pediatrics website over the last week, and catch up on anything you may have missed.

An 11-year-old boy with a history of asthma and allergic rhinitis presented to the emergency department (ED) with worsening fatigue, minimal responsivity to external stimuli, and diffuse muscle weakness for 2 months.

ConSynance Therapeutics' CSTI-500, an innovative Triple Monoamine Reuptake Inhibitor, has received FDA's Rare Pediatric Disease Designation for treating Prader-Willi Syndrome in children.

The submission to the FDA includes data from the phase 2b ReNeu trial of patients aged 2 years and older with NF1-associated PN causing significant morbidity.

The decision makes pitolisant the first and only FDA-approved, non-scheduled treatment option for daytime sleepiness in this patient population.

The company also announced that it has surpassed its interim analysis enrollment target and expects topline phase 3 data from the FORTIFY study (NCT05775848) among individuals with LGMD21/R9 in 2025.

Approximately half of study participants had tried lifestyle modifications and used vitamin supplementation, and most were taking multiple medications.

The analysis was based on 573 hospitalizations (most patients had an average of 2 hospitalization episodes) in which new BCs were drawn more than 48 hours after initial cultures were negative.

The maximum daily dose has increased from 80 mg to 100 mg.

With the approval comes the immediate availability of 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg doses for patients between 2 to 5 years of age.

The decision makes givinostat the first nonsteroidal drug approved to treat patients with all genetic variants of DMD.

The approach can improve mental health and various subgroups such as cognitive function, psychological well-being, and more.

William Gallentine, DO, explains why he is excited for the year ahead when it comes to epilepsy treatment as new technologies emerge and the treatment landscape changes.

Review some of the top stories from the Contemporary Pediatrics website over the last week, and catch up on anything you may have missed.

Review some of the top stories from the Contemporary Pediatrics website over the last week, and catch up on anything you may have missed.

In a recent study, improved neurodevelopmental outcomes were seen in children aged 2 years whose mothers received a Mediterranean diet or mindfulness-based stress reduction intervention during pregnancy.

Watch as Rob Knight, PhD, Wolfe Endowed Chair in Microbiome Science at Rady Children's Hospital-San Diego, professor of pediatrics, UCSD, talks the gut microbiome and the potential associations with cognitive and neurological conditions in children, and why the topic is gaining interest and momentum.

In a recent study, Developmental Assessment of Young Children, second edition scores for neurodevelopmental outcomes did not differ between infants exposed to maternal COVID-19 during pregnancy and those not exposed.

Delaying diagnosis and treatment for this early childhood disorder can lead to worse outcomes, so early recognition is crucial.

At 2 years post-pediatric epilepsy surgery, 72% of patients were seizure-free compared to 33% of medically-treated patients.

In a recent study, female offspring of mothers with a positive COVID-19 test during pregnancy were at a decreased risk of developing neurodevelopmental disorders compared to male offspring.

A study found that children with acute concussions could have less symptom burden with an earlier return to school.

In a recent study, worse neurodevelopmental outcomes were seen in children born preterm and with postnatal growth failure.

In a recent study, maternal depression during pregnancy was associated with offspring brain age, while recent stress in offspring was associated with a greater aging pace.

In a recent study, young children with severe traumatic brain injury (TBI) showed significantly worse cognition and academic scores than children with mild TBI or other injury.

Children definite motor problems were more likely to have psychotic experiences compared to children with no definite motor problems.

The strongest confounders were family income, caregiver education, and ADHD polygenic risk scores for ADHD clinical range diagnoses.

This brain imaging study was the first to look at the position of depression and systemic inflammation in brain measures while including the largest sample of patients with psoriasis to date.

In a recent study, investigators found that life-threatening neurologic conditions from severe acute COVID-19 were more frequent in 2021 than 2020.

In a recent study, patients with low amounts of screen time following concussion had similar rates of symptoms as those with high amounts of screen time.