Adverse childhood experiences (ACE) can have a wretchedly direct relationship to lifelong troubles in adulthood, troubles that can be best fixed in childhood. That's one of the result of the ACE study, according to one of its principal investigators, Vincent Felitti, MD, professor at UC San Diego. From a sample of over seventeen thousand adults, the ACE study team asked about the prevalence of ten traumatic childhood events in three categories: abuse, neglect, and household dysfunction. Specific experiences includes loss of a parent, physical abuse, and mental abuse.