
For years we have been prescribing prophylactic antibiotic therapy for children with a first-time urinary tract infection (UTI) before obtaining imaging studies-as is recommended in the 1999 American Academy of Pediatrics' practice parameter1-and for those with vesiculoureteral reflux (VUR). Although many pediatricians have raised questions about the efficacy and safety of this practice, the risks and benefits of antibiotic prophylaxis have not been well studied.