Simple interventions improve pediatrician adherence to peanut allergy prevention guidelines

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Article

Training tools and EHR prompts boosted pediatricians’ adherence to early peanut introduction guidelines in a new trial.

Simple interventions improve pediatrician adherence to peanut allergy prevention guidelines | Image Credit: ©  Stepan Popov - stock.adobe.com.

Simple interventions improve pediatrician adherence to peanut allergy prevention guidelines | Image Credit: © Stepan Popov - stock.adobe.com.

Takeaways

  • Structured tools work: Embedding EHR prompts and clinician training boosted adherence from 35% to over 80% for low-risk infants.
  • Busy visits need support: Streamlined resources help pediatricians deliver guideline-based counseling in time-limited well visits.
  • Prevention potential: Widespread adoption of early introduction protocols could reduce peanut allergy prevalence in US children.

Since 2017, the US Addendum Guidelines for the Prevention of Peanut Allergy have encouraged clinicians to introduce peanut-containing foods to infants aged 4 to 6 months to reduce the risk of peanut allergy (PA). Despite these recommendations, guideline adherence among pediatricians has remained low.1,2

  • Peanut allergy is the most common pediatric food allergy, affecting more than 2% of US children.
  • Early introduction of peanut products can reduce allergy risk by over 80%, based on prior landmark studies.
  • The Intervention to Reduce Early Peanut Allergy in Children (iREACH) Trial, led by Northwestern University Feinberg School of Medicine and Ann & Robert H. Lurie Children’s Hospital of Chicago, aimed to increase clinician adherence using practical, scalable tools.

Study design

The iREACH trial was a practice-based, cluster-randomized study involving 30 pediatric practices across the Chicago and Peoria, Illinois, regions, including federally qualified health centers, private clinics, and academic practices.

  • Intervention group: received a training video, electronic health record (EHR) prompts, visual aids for parents, and a scorecard to identify severe eczema.
  • Control group: did not receive any tools or training.
  • Population: 18,480 infants seen by 290 clinicians during 4- or 6-month well-child visits.
  • Primary outcome: clinician adherence to the 2017 peanut allergy prevention guidelines, measured via EHR data.

Clinician adherence definitions:

  • Low-risk infants (no or mild/moderate eczema, no egg allergy): recommending early peanut introduction.
  • High-risk infants (severe eczema and/or egg allergy): ordering a peanut-specific immunoglobulin E test, counseling, or referring to an allergist.

Key findings

The results demonstrated a significant improvement in adherence among intervention practices:

  • Low-risk infants: 83.7% adherence in intervention vs 34.7% in control (OR 14.6; 95% CI, 7.0–30.5; P < .001).
  • High-risk infants: 26.8% adherence in intervention vs 10.4% in control (OR 3.1; 95% CI, 1.1–8.8; P = .03).
  • Allergist referrals/testing: 36% in intervention vs 10% in control.

Lead author Ruchi Gupta, MD, MPH, professor of pediatrics and medicine at Northwestern University Feinberg School of Medicine and pediatrician at Lurie Children’s, emphasized the importance of structural supports for busy practices:

“We found that supporting pediatricians with training, electronic health record prompts and educational materials for parents significantly improved their ability to counsel families on early peanut introduction,” said Gupta.

She added, “Because pediatric visits at 4 and 6 months are so busy, this support is critical to ensure families receive clear guidance. Our hope is that these conversations will help parents feel confident introducing peanut products early. We want to reverse the trend of increasing food allergies in the United States through prevention.”

Lucy Bilaver, PhD, associate professor of pediatrics at Feinberg and lead statistician for the study, highlighted the use of EHR data. “We were able to measure the primary outcome by making use of the clinical notes and structured data that pediatric clinicians generate during these well-child visits,” she said.

Implications for practice

The study underscores that low-cost, easy-to-implement interventions can significantly improve pediatrician adherence to peanut allergy prevention guidelines.

  • EHR prompts, visual decision aids, and parent handouts represent practical solutions that can be scaled across diverse practice settings.
  • The trial supports early peanut introduction as an effective preventive strategy for food allergy in infancy.
  • Long-term follow-up will continue until children reach 2.5 years to determine whether improved clinician adherence reduces the actual prevalence of peanut allergy.

Gupta noted, “While more work is needed, the success of this intervention supports wider dissemination to prevent peanut allergy in children.”

References:

  1. Northwestern University. New tools boost pediatricians’ adherence to peanut allergy guidelines 15-fold. Eurekalert. October 6, 2025. Accessed October 7, 2025. https://www.eurekalert.org/news-releases/1100712
  2. Gupta RS, Bilaver LA, Jiang J, et al. Pediatric Clinician Adherence to Peanut Allergy Prevention Guidelines: A Randomized Trial. Pediatrics. Published online October 6, 2025. doi:https://doi.org/10.1542/peds.2025-071233

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