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Researchers at Wisconsin Children’s Hospital in Milwaukee, Wisconsin, found that 100 children who visited a pediatric emergency department (ED) with a reported history of penicillin allergy based on low-risk symptoms all had negative allergy testing for penicillin and all tolerated a penicillin challenge (500 mg of oral amoxicillin) without developing a severe allergic reaction. Penicillin allergy labels were removed from these children’s hospital medical records.

The worried mother of an 11-year-old boy arrives at the office for evaluation of an asymptomatic bumpy rash that appeared suddenly in his right groin a month ago, and that has now extended all the way down to his right ankle. What's the diagnosis?

When you approach a parent who is hesitant about vaccinating her infant at the appropriate well-baby visits, perhaps you say something like this: “Well, we have to do some shots.” Or you might say, “How do you feel about vaccines today?” The former strategy (a “presumptive” approach) is more likely to be effective than the latter (a “participatory” approach), according to a study in parents whom a standardized survey classified as being hesitant about vaccines.

A 16-year-old boy develops a diffuse, rapidly progressive eruption on his trunk, face, and extremities 4 days after starting oral amoxicillin for presumed strep throat. He presents to the emergency department (ED) where Stevens-Johnson syndrome is considered. The ED physician notes no mucous membrane involvement.

Investigators compared the accuracy of an American Academy of Pediatrics (AAP) practice guideline algorithm for diagnosing of urinary tract infection (UTI) in 2- to 23-month-olds with a new tool (UTICalc; University of Pittsburgh, Pennsylvania) that first estimates UTI probability based on clinical variables and then, if laboratory testing is performed, updates the estimate based on the results.