It was my first day back at the office after a 2-month medical leave, which included 14 days of hospitalization for severe depression. I'd had plenty of time to ponder whether this was an endogenous or exogenous depression. There were many things that could have caused me to be depressed: the death of my wife a few years ago, a pediatric career devoted-in large part-to abused children, conflicts between the medical school and the hospital, administrative decisions forcing my division to "do more with less" that made life difficult, and a general pervasive attitude that making a profit mattered above anything else.